Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo.

@article{McDonald2003RelaxinIU,
  title={Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo.},
  author={G. A. McDonald and P. Sarkar and H. Rennke and E. Unemori and R. Kalluri and V. Sukhatme},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={285 1},
  pages={
          F59-67
        }
}
Fibronectin, a large adhesive glycoprotein, is a prominent constituent of the extracellular matrix. Abnormalities in fibronectin homeostasis occur in numerous disease states, ranging from primary fibrosing conditions to neoplastic transformation. We demonstrate that fibronectin is a target protein substrate for ubiquitin-dependent degradation. Coimmunoprecipitation experiments and confocal microscopy demonstrated ubiquitin-fibronectin interaction. In an in vitro model of renal fibrosis, relaxin… Expand
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