Relaxin increases secretion of tissue inhibitor of matrix metalloproteinase-1 and -2 during uterine and cervical growth and remodeling in the pig.

@article{Lenhart2002RelaxinIS,
  title={Relaxin increases secretion of tissue inhibitor of matrix metalloproteinase-1 and -2 during uterine and cervical growth and remodeling in the pig.},
  author={Judy A Lenhart and Peter L. Ryan and Kathleen M. Ohleth and Stephen S. Palmer and Carol A Bagnell},
  journal={Endocrinology},
  year={2002},
  volume={143 1},
  pages={
          91-8
        }
}
Remodeling of reproductive organs during pregnancy requires degradation and resynthesis of structural barriers to cell invasion. Matrix metalloproteinases (MMPs) are enzymes that break down components of the extracellular matrix (ECM) and are essential for tissue remodeling processes. Tissue inhibitors of metalloproteinases (TIMPs) are important regulators of MMP activity. In the pig, relaxin stimulates growth and remodeling of the uterus and cervix during pregnancy, effects that include the… 
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Abnormal extracellular matrix remodelling in the cervix of pregnant relaxin-deficient mice is not associated with reduced matrix metalloproteinase expression or activity.
TLDR
Relaxin deficiency results in increased cervical collagen in late pregnancy, which is not explained by a reduction in Mmp expression or activity or decreased Rxfp1, however, an imbalance between Esr1 and Esr2 may be involved.
Relaxin Enhances the Collagenolytic Activity and In Vitro Invasiveness by Upregulating Matrix Metalloproteinases in Human Thyroid Carcinoma Cells
TLDR
Enhanced tumor cell invasion by RLN2 involves the formation of MT1-MMP–enriched invadopodia that lead to increased collagenolytic cell invasionBy human thyroid cancer cells.
The role and regulation of the uterine matrix metalloproteinase system in menstruating and non-menstruating species.
TLDR
The uterus undergoes dynamic tissue remodeling throughout each reproductive cycle, which is regulated in part by the matrix metalloproteinases (MMP) system, which act in concert to modulate extracellular matrix turnover and cell behaviors and thus play a key role in many physiologic and pathologic conditions throughout the body.
Relaxin Modulates Collagen Type I and Matrix Metalloproteinase-1 Expression by Human Periodontal Ligament Cells
Temporal Changes in Matrix Metalloproteinases, Their Inhibitors, and Cathepsins in Mouse Pubic Symphysis During Pregnancy and Postpartum
TLDR
Findings indicate that during pregnancy and postpartum there are variations in the expression and activity of proteins that may have an important role in remodeling the pubic symphysis during these events.
Mechanisms of Relaxin Action in the Reproductive Tract: Studies in the Relaxin‐Deficient (Rlx−/−) Mouse
TLDR
Examination of phenotypic differences in collagen, matrix metalloproteinases (MMP), and estrogen receptors (ERs) in the cervix and vagina of pregnant Rlx+/+ and R lx−/− mice shows increases in MMP gene expression in RlX−/+ mice that are not correlated with changes in collagen expression.
Angiogenesis , Metastasis , and the Cellular Microenvironment Relaxin Enhances the Collagenolytic Activity and In Vitro Invasiveness by Upregulating Matrix Metalloproteinases in Human Thyroid Carcinoma Cells
TLDR
Enhanced tumor cell invasion by RLN2 involves the formation of MT1-MMP–enriched invadopodia that lead to increased collagenolytic cell invasionBy human thyroid cancer cells.
Effects of relaxin on collagen type I released by stretched human periodontal ligament cells.
TLDR
Investigation of the effects of relaxin on the expression of collagen type I (Col-I) and matrix metalloproteinase 1 (MMP-1) in stretched hPDL cells in vitro indicates that this hormone may be useful to prevent orthodontic relapse following orthodentic treatment.
Relaxin and the extracellular matrix: molecular mechanisms of action and implications for cardiovascular disease.
TLDR
Research on the anti-fibrotic actions of relaxin is summarized, the potential mechanisms by which relaxin regulates the ECM in cardiovascular tissues are outlined and the implications of this research for the management of heart disease are examined.
Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss
TLDR
Women with a history of RPL demonstrate increased serum TIMP-2 and reduced RLX-2 during a subsequent viable pregnancy, which suggest roles for these two peptides in early implantation and placental development.
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