Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.

@article{Hudson1984RelaxinGE,
  title={Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.},
  author={Peter Hudson and M John and Robert Crawford and J. Haralambidis and Denis Scanlon and Jason Gorman and Geoffrey W. Tregear and John Shine and Hugh D. Niall},
  journal={The EMBO journal},
  year={1984},
  volume={3 10},
  pages={2333-9}
}
In earlier studies we identified in a human genomic library a gene (human relaxin gene H1) coding for a relaxin-related peptide. We now have evidence that the human genome possesses an additional relaxin-related gene (designated human relaxin gene H2) which appears to be selectively expressed in the ovary during pregnancy. Nucleotide sequence analysis revealed striking differences in the predicted structures of relaxin encoded by these two genes. Chemical synthesis of biologically active… CONTINUE READING