Relaxin family peptides in the male reproductive system--a critical appraisal.

@article{Ivell2011RelaxinFP,
  title={Relaxin family peptides in the male reproductive system--a critical appraisal.},
  author={Richard Ivell and Malgorzata Kotula-Balak and Danielle J. Glynn and Kee Heng and Ravinder J K Anand-Ivell},
  journal={Molecular human reproduction},
  year={2011},
  volume={17 2},
  pages={71-84}
}
The human genome project has identified, besides ovarian relaxin (RLN), six other relaxin-like molecules (RLN3, H1-RLN, INSL3-6), most of which appear to be expressed in the testis and/or male reproductive system, together with four different G-protein-coupled receptors responsive to one or other of these peptides. Earlier work on relaxin in the male assumed the simplistic hypothesis of only a single relaxin-like entity. This review systematically examines the expression and physiology of… CONTINUE READING
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