Relaxin augments BMP-2-induced osteoblast differentiation and bone formation.

@article{Moon2014RelaxinAB,
  title={Relaxin augments BMP-2-induced osteoblast differentiation and bone formation.},
  author={J S Moon and Sun-Hun Kim and S S Oh and Yong-Wook Jeong and Jee-Hae Kang and Jong-Chun Park and Hye-Ju Son and Suk Chul Bae and Byung-Il Park and Min-Seok Kim and Jeong-Tae Koh and H M Ko},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2014},
  volume={29 7},
  pages={1586-96}
}
Relaxin (Rln), a polypeptide hormone of the insulin superfamily, is an ovarian peptide hormone that is involved in a diverse range of physiological and pathological reactions. In this study, we investigated the effect of Rln on bone morphogenetic protein 2 (BMP-2)-induced osteoblast differentiation and bone formation. Expression of Rln receptors was examined in the primary mouse bone marrow stem cells (BMSCs) and mouse embryonic fibroblast cell line C3H/10T1/2 cells by RT-PCR and Western blot… CONTINUE READING

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