Relaxin: new pathophysiological aspects and pharmacological perspectives for an old protein.

@article{Cernaro2014RelaxinNP,
  title={Relaxin: new pathophysiological aspects and pharmacological perspectives for an old protein.},
  author={Valeria Cernaro and Antonio Lacquaniti and Rosaria Lupica and Antoine Buemi and Domenico Trimboli and Grazia Giorgianni and Davide Bolignano and Michele Buemi},
  journal={Medicinal research reviews},
  year={2014},
  volume={34 1},
  pages={77-105}
}
Human relaxin-2 (hereafter simply defined as "relaxin") is a 6-kDa peptidic hormone best known for the physiological role played during pregnancy in the growth and differentiation of the reproductive tract and in the renal and systemic hemodynamic changes. This factor can also be involved in the pathophysiology of arterial hypertension and heart failure, in the molecular pathways of fibrosis and cancer, and in angiogenesis and bone remodeling. It belongs to the relaxin peptide family, whose… CONTINUE READING

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