Relaxin: a disulfide homolog of insulin.

@article{Schwabe1977RelaxinAD,
  title={Relaxin: a disulfide homolog of insulin.},
  author={Christian Schwabe and Jennifer K McDonald},
  journal={Science},
  year={1977},
  volume={197 4306},
  pages={914-5}
}
Relaxin, a peptide hormone responsible for the widening of the birth canal in mammals, has been purified from the ovaries of pregnant hogs. The amino acid sequences of its constituent A and B chains were determined, and the positions of the disulfide cross-links were established. Relaxin was shown to be identical to insulin with respect to its disulfide bond distribution, but significant homology was lacking in other positions. These findings suggest that relaxin and insulin were derived from a… CONTINUE READING

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