Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants

@article{Naqvi2005RelaxinsIO,
  title={Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants},
  author={Tabassum Naqvi and Trang T Duong and Gihan Hashem and Momotoshi Shiga and Qin Zhang and Sunil Kapila},
  journal={Arthritis Research & Therapy},
  year={2005},
  volume={7},
  pages={R1 - R11}
}
Diseases of specific fibrocartilaginous joints are especially common in women of reproductive age, suggesting that female hormones contribute to their etiopathogenesis. Previously, we showed that relaxin dose-dependently induces matrix metalloproteinase (MMP) expression in isolated joint fibrocartilaginous cells. Here we determined the effects of relaxin with or without beta-estradiol on the modulation of MMPs in joint fibrocartilaginous explants, and assessed the contribution of these… CONTINUE READING
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Female hormones modulate matrix loss from TMJ and symphyseal fibrocartilages

  • G Hashem, Q Zhang, T Hayami, S Kapila
  • J Dent Res
  • 2004
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