Relaxation of sheep urethral muscle induced by electrical stimulation of nerves: involvement of nitric oxide.

@article{GarciaPascual1991RelaxationOS,
  title={Relaxation of sheep urethral muscle induced by electrical stimulation of nerves: involvement of nitric oxide.},
  author={Angeles Garcia-Pascual and Gonzalo Costa and Albino Garc{\'i}a-Sacrist{\'a}n and Karl-Erik Andersson},
  journal={Acta physiologica Scandinavica},
  year={1991},
  volume={141 4},
  pages={531-9}
}
Isolated smooth muscle preparations from the sheep urethra responded to electrical field stimulation with contraction when basal tension was low (5-6 mN), but with relaxation when the preparations were contracted with noradrenaline (NA), clonidine, or prostaglandin F2a. No relaxant response could be elicited in high K+ (124 mM) contracted preparations. Electrically induced relaxations had a threshold of less than 1 Hz and a maximum at 8 Hz. Both contractant and relaxant responses were abolished… CONTINUE READING

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