Relaxation of isolated guinea pig trachea by genistein via inhibition of phosphodiesterase.

@article{Lin2007RelaxationOI,
  title={Relaxation of isolated guinea pig trachea by genistein via inhibition of phosphodiesterase.},
  author={Ching-Chi Lin and Junn-Lain Chen and Wun-Chang Ko},
  journal={Planta medica},
  year={2007},
  volume={73 4},
  pages={
          323-9
        }
}
We investigated the mechanisms of the relaxant action of genistein, an isoflavone, phytoestrogen and non-specific protein tyrosine kinase inhibitor. Changes in tension of guinea pig tracheal segments were isometrically recorded on a polygraph. Genistein concentration-dependently relaxed histamine (30 microM)-, carbachol (0.2 microM)-, KCl (30 mM)- and leukotriene D4 (10 nM)-induced precontractions and inhibited cumulative histamine- and carbachol-induced contractions in a non-competitive manner… Expand
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