Relaxation of isolated guinea pig trachea by genistein via inhibition of phosphodiesterase.

  title={Relaxation of isolated guinea pig trachea by genistein via inhibition of phosphodiesterase.},
  author={Ching-Chi Lin and Junn-Lain Chen and Wun-Chang Ko},
  journal={Planta medica},
  volume={73 4},
We investigated the mechanisms of the relaxant action of genistein, an isoflavone, phytoestrogen and non-specific protein tyrosine kinase inhibitor. Changes in tension of guinea pig tracheal segments were isometrically recorded on a polygraph. Genistein concentration-dependently relaxed histamine (30 microM)-, carbachol (0.2 microM)-, KCl (30 mM)- and leukotriene D4 (10 nM)-induced precontractions and inhibited cumulative histamine- and carbachol-induced contractions in a non-competitive manner… Expand
Genistein, a competitive PDE1-4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects.
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The aim of this review is to present available data on the effects of plant extracts and individual secondary plant metabolites which can be potentially used as feed additives on gastrointestinal motility and to generalize that most essential oils, tannins and saponins which are under consideration as phytogenic feed additives generate myorelaxant effects towards gastrointestinal tissues. Expand