Relaxation of depolarized guinea pig taenia caecum induced by some antispasmodics.

@article{Takayanagi1978RelaxationOD,
  title={Relaxation of depolarized guinea pig taenia caecum induced by some antispasmodics.},
  author={Issei Takayanagi and Akira Karasawa and Yutaka Kasuya},
  journal={European journal of pharmacology},
  year={1978},
  volume={50 2},
  pages={
          137-43
        }
}
Taenia isolated from the guinea pig caecum were used for the experiments. No inhibitory response of the depolarized taenia to isoprenaline was observed during the significant increase of cyclic AMP level. These observations suggest that the total tissue level of cyclic AMP is not an important determinant of relaxation in the depolarized taenia. Antispasmodics, such as papaverine, benactyzine and Aspaminol (1,1-diphenyl-3-piperidino-butanol hydrochloride) relaxed the depolarized taenia, while… 
29 Citations
Mechanisms of inhibitory action of phenylephrine in guinea-pig taenia coli.
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The findings suggest that the inhibition of Ca-influx in the taenia coli may be involved in the phenylephrine-induced relaxation in the partly depolarized tissue.
Mechanism of relaxant action of papaverine. Effect on caffeine-induced contraction of guinea pig taenia coli.
TLDR
It is considered that papaverine increases cyclic AMP of the taenia coli, and this increased cyclicAMP stimulates accumulation of calcium ion into its storage sites from where calcium ion was released by caffeine, finally leading to smooth muscle relaxation.
Inhibitory alpha-adrenergic action of phenylephrine in guinea pig taenia caecum.
TLDR
Phenylephrine, a selective alpha-adrenergic stimulant, caused a maximal relaxation of the taenia from guinea pig caecum in the concentration of 10(-6) g/ml and abolished the spontaneous spike discharge.
Effects of nonspecific smooth muscle relaxants on glycogen phosphorylase activity in depolarized taenia caecum of guinea pig.
TLDR
Effects of papaverine, Aspaminol (an antispasmodic drug), D-600, 2, 4-dinitrophenol and Ca ions on glycogen phosphorylase activity in the KCl-depolarized taenia caecum of guinea pig were tested, indicating that Ca ions, which entered the smooth muscle cells, played an important role in the regulation of phosphate activity.
Mechanisms of spasmolytic action of bile salts in depolarized guinea-pig taenia coli.
TLDR
It is suggested that the bile salts, like papaverine, may exert their spasmolytic action through accelerating the Ca-efflux and inhibiting theCa-influx of the smooth muscle cells.
Effects of nonspecific smooth muscle relaxants on calcium-uptake by microsomal fraction and their inhibitory action in rabbit taenia coli.
TLDR
It is suggested that Aspaminol competes with Ca ions at a surface site of muscle membrane concerned with Ca-uptake process, thus decreasing the supply of Ca ions to the contractile elements and that papaverine may have inhibitory actions on Ca-ptake by the microsomal fraction in addition to stimulatory action which seems to be mediated through cyclic AMP.
Mechanism of relaxant action of papaverine IV. Roles of sodium ion and cyclic AMP.
TLDR
The influence of manipulating external sodium ion concentration on the relaxant effects of papaverine, dibutyryl cyclic AMP and deoxycholate were compared in guinea-pig taenia coli to indicate that the relaxants activity of papaversine is greatly reduced in the absence of external Sodium ion.
Mechanism of relaxant action of papaverine. III. Comparison of sodium ion dependencies on the relaxant effects of papaverine, Aspaminol and benactyzine in guinea-pig taenia coli.
TLDR
It is suggested that papaverine may induce the smooth muscle relaxation not only by inhibiting the Ca-influx independently of the presence of sodium ion but also by other mechanisms sensitive to sodium ion, by contrast, Aspaminol and benactyzine may evoke the relaxation through mechanisms less sensitive to the presenceof sodium ion.
Effects of nonspecific smooth muscle relaxants and Ca-blocker on Ca-release and Ca-binding in microsomal fractions from rabbit taenia coli.
TLDR
Effects of nonspecific smooth muscle relaxants and Aspaminol on Ca-release and Ca-binding in the microsomal fractions of rabbit taenia coli were determined and changes observed in Ca-transfer may be related to relaxation of smooth muscle induced by the test drugs.
Comparison of effects of smooth muscle relaxing drugs in intestinal smooth muscle of guinea pig.
  • T. Mukai
  • Chemistry, Medicine
    Journal of pharmacobio-dynamics
  • 1983
TLDR
The results suggest that these seven relaxants can be divided into four types, and influence of those relaxants on spontaneously- and Ba2+-evoked electrical activities are compatible with the above differentiation.
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