Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

@inproceedings{Chiaruttini2015RelaxationOL,
  title={Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation},
  author={Nicolas Chiaruttini and Lorena Redondo-Morata and Adai Colom and Fr{\'e}d{\'e}ric Humbert and Martin Lenz and Simon Scheuring and Aur{\'e}lien Roux},
  booktitle={Cell},
  year={2015}
}
ESCRT-III is required for lipid membrane remodeling in many cellular processes, from abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III polymerization generates membrane curvature remains debated. Here, we show that Snf7, the main component of ESCRT-III, polymerizes into spirals at the surface of lipid bilayers. When covering the entire membrane surface, these spirals stopped growing when densely packed: they had a polygonal shape, suggesting that lateral… CONTINUE READING

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