Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

  title={Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation},
  author={Nicolas Chiaruttini and Lorena Redondo-Morata and Adai Colom and Fr{\'e}d{\'e}ric Humbert and Martin Lenz and Simon Scheuring and Aur{\'e}lien Roux},
ESCRT-III is required for lipid membrane remodeling in many cellular processes, from abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III polymerization generates membrane curvature remains debated. Here, we show that Snf7, the main component of ESCRT-III, polymerizes into spirals at the surface of lipid bilayers. When covering the entire membrane surface, these spirals stopped growing when densely packed: they had a polygonal shape, suggesting that lateral… CONTINUE READING


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bending by protein-protein crowding

  • A. C. Sundborger, S. Fang, J. A. Heymann, P. Ray, J. S. Chappie, J. E. Hinshaw
  • Nat. Cell Biol
  • 2014
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