Relaxation in ferret ventricular myocytes: role of the sarcolemmal Ca ATPase

  title={Relaxation in ferret ventricular myocytes: role of the sarcolemmal Ca ATPase},
  author={Rosana Almada Bassani and Jos{\'e} Wilson Magalh{\~a}es Bassani and Donald M. Bers},
  journal={Pfl{\"u}gers Archiv},
In ferret ventricular myocytes the rate of intracellular Ca concentration [Ca]i decline and relaxation is remarkably fast (compared with rabbit and rat) under conditions where both the sarcoplasmic reticulum Ca uptake and Na/Ca exchange are inhibited. Here we explore the possibility that this rapid [Ca]i decline in ferret cells is attributable to the sarcolemmal Ca ATPase by using carboxyeosin (a potent inhibitor of the sarcolemmal Ca-ATPase). We compare the effects of carboxyeosin with those… CONTINUE READING

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