Relaxation and fluctuations of membrane currents that flow through drug-operated channels

@article{Colquhoun1977RelaxationAF,
  title={Relaxation and fluctuations of membrane currents that flow through drug-operated channels},
  author={David Colquhoun and Alan G. Hawkes},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1977},
  volume={199},
  pages={231 - 262}
}
  • D. Colquhoun, A. Hawkes
  • Published 14 November 1977
  • Biology
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
The theoretical background is presented for (a) the relaxation towards equilibrium of drug-induced membrane currents, and (b) the fluctuations of membrane current about its equilibrium value that originate in the opening and closing of membrane ion channels. General expressions are given that relate the relaxation current, autocovariance function, spectral density function, fluctuation variance and mean open channel lifetime to the rate constants and single channel conductances for any theory… 

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