Relaxant effects of forskolin on guinea pig tracheal smooth muscle

@article{Tsukawaki1987RelaxantEO,
  title={Relaxant effects of forskolin on guinea pig tracheal smooth muscle},
  author={Masao Tsukawaki and Kiyoshi Suzuki and Ryujiro Suzuki and Kenzo Takagi and Tatsuo Satake},
  journal={Lung},
  year={1987},
  volume={165},
  pages={225-237}
}
We investigated the relaxant effects of forskolin, a diterpene derivative isolated from the roots ofColeus forskohlii, on guinea pig airway smooth muscle by measuring the isometric tension of tracheal smooth muscle in vitro and transcutaneous Po2 during the histamine inhalation test (HIT) in vivo. Forskolin (10−9–10−5 M) caused dose-dependent relaxant effects on resting tone and on leukotriene C4 (10−7 M)-, leukotriene D4 (10−7 M)-, and carbachol (3 × 10−6 M)-induced contraction of tracheal… CONTINUE READING