Relaxant effects of amrinone upon pulmonary smooth muscle.

  title={Relaxant effects of amrinone upon pulmonary smooth muscle.},
  author={Z. E. Mielens and Dave C Buck},
  volume={25 5},
Amrinone, a cardiac positive inotropic agent, inhibited histamine-induced bronchoconstriction in a dose-related manner in dogs when administered intra-duodenally at doses ranging from 0.3 to 10 mg/kg. This bronchodilatory property of amrinone in vivo was confirmed in vitro: amrinone relaxed carbachol-induced contractions and it inhibited Ba2+- or histamine… CONTINUE READING