Relaxant effect of calcitonin gene-related peptide on cerebral arterial spasm induced by experimental subarachnoid hemorrhage in dogs.

@article{Nozaki1989RelaxantEO,
  title={Relaxant effect of calcitonin gene-related peptide on cerebral arterial spasm induced by experimental subarachnoid hemorrhage in dogs.},
  author={Kazuhiko Nozaki and Yoshio Uemura and Sh. Okamoto and H. Ishikura K. Kikuchi and Noboru Mizuno},
  journal={Journal of neurosurgery},
  year={1989},
  volume={71 4},
  pages={558-64}
}
This study examines the relaxant effect of calcitonin gene-related peptide (CGRP), a 37-amino acid peptide with a potent vasodilator action, on cerebral arterial spasm after subarachnoid hemorrhage (SAH). The spasm was induced by injecting autologous arterial blood percutaneously into the cisterna magna in adult mongrel dogs. The single-injection model of SAH was produced by injection of 1.0 ml/kg body weight of blood (on Day 0), and the double-injection model involved two successive injections… CONTINUE READING