Relaxant and contractile responses to prostaglandins in premature, newborn and adult baboon cerebral arteries.


Dose-dependent actions of prostaglandins (PGs) were investigated on cerebral arterial strips isolated from premature, newborn and adult baboons. PGE1 an PGE2 in low concentrations (10(-9) to 10(-7) M) elicited significant relaxation in both premature and newborn baboon cerebral arteries. Arteries from adult baboons showed slight or small relaxation in… (More)


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