Relaxant Effect of Tetrazepam on Rat Uterine Smooth Muscle: Role of Calcium Movement

@article{PrezGuerrero1996RelaxantEO,
  title={Relaxant Effect of Tetrazepam on Rat Uterine Smooth Muscle: Role of Calcium Movement},
  author={Concepci{\'o}n P{\'e}rez-Guerrero and Mar{\'i}a Dolores Herrera and Elisa Marhuenda},
  journal={Journal of Pharmacy and Pharmacology},
  year={1996},
  volume={48}
}
Tetrazepam is a benzodiazepine derivative clinically used as a muscle relaxant. The aim of the present work was to examine its effect on uterine smooth muscle of the rat in estrus. 
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5 Citations

5 Citations

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Citation Type

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The mechanism of action of zolpidem may be related to an action on Ca2+ influx through voltage-dependent Ca2-free depolarizing medium due to an interaction with low affinity receptor located at the plasmalemma as has been suggested for diazepam.
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It is suggested that tetrazepam inhibits the contractile responses to guinea-pig ileum and rat duodenum, probably through a reduction of calcium influx by way of calcium channels and these events are not related to high-affinity peripheral benzodiazepine binding sites.
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Based on the inhibitory effect of the extracts on the oxytocin-induced contraction, it is concluded that the extracts might be useful as tocolytic agents for the prevention of preterm labor.
Flunitrazepam induces geometrical changes at the lipid-water interface.
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An FNTZ-induced expansion of dpPC-water interface region affected the constraints imposed on the lipid-water system by the molecular geometry, interacting free energies and entropy that determine the shape of a multimolecular structure.

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