Relaxant Effect of Tetrazepam on Rat Uterine Smooth Muscle: Role of Calcium Movement

@article{PrezGuerrero1996RelaxantEO,
  title={Relaxant Effect of Tetrazepam on Rat Uterine Smooth Muscle: Role of Calcium Movement},
  author={Concepci{\'o}n P{\'e}rez-Guerrero and Mar{\'i}a Dolores Herrera and Elisa Marhuenda},
  journal={Journal of Pharmacy and Pharmacology},
  year={1996},
  volume={48}
}
Tetrazepam is a benzodiazepine derivative clinically used as a muscle relaxant. The aim of the present work was to examine its effect on uterine smooth muscle of the rat in estrus. 
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The mechanism of action of zolpidem may be related to an action on Ca2+ influx through voltage-dependent Ca2-free depolarizing medium due to an interaction with low affinity receptor located at the plasmalemma as has been suggested for diazepam.
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It is suggested that tetrazepam inhibits the contractile responses to guinea-pig ileum and rat duodenum, probably through a reduction of calcium influx by way of calcium channels and these events are not related to high-affinity peripheral benzodiazepine binding sites.
Spasmolytic Effect of Papaya (Carica papaya L.) Leave Alkaloid on Isolated Rat Myometrial Contraction in vitro
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Results indicated that PA was a uterine relaxant on isolated rat uterus in vitro, and was able to inhibit uterine contraction stimulated by various uterine stimulants such as acetylcholine, oxytocinand prostaglandin F2alpha.
Flunitrazepam induces geometrical changes at the lipid-water interface.

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