Relaxant Effect of Tetrazepam on Rat Uterine Smooth Muscle: Role of Calcium Movement

  title={Relaxant Effect of Tetrazepam on Rat Uterine Smooth Muscle: Role of Calcium Movement},
  author={Concepci{\'o}n P{\'e}rez-Guerrero and Mar{\'i}a Dolores Herrera and Elisa Marhuenda},
  journal={Journal of Pharmacy and Pharmacology},
Tetrazepam is a benzodiazepine derivative clinically used as a muscle relaxant. The aim of the present work was to examine its effect on uterine smooth muscle of the rat in estrus. 
Uterine Relaxant Effect of Zolpidem: A Comparison with Other Smooth Muscle Relaxants
The mechanism of action of zolpidem may be related to an action on Ca2+ influx through voltage-dependent Ca2-free depolarizing medium due to an interaction with low affinity receptor located at the plasmalemma as has been suggested for diazepam.
Spasmolytic effects of tetrazepam on rat duodenum and guinea-pig ileum.
It is suggested that tetrazepam inhibits the contractile responses to guinea-pig ileum and rat duodenum, probably through a reduction of calcium influx by way of calcium channels and these events are not related to high-affinity peripheral benzodiazepine binding sites.
Spasmolytic Effect of Papaya (Carica papaya L.) Leave Alkaloid on Isolated Rat Myometrial Contraction in vitro
Results indicated that PA was a uterine relaxant on isolated rat uterus in vitro, and was able to inhibit uterine contraction stimulated by various uterine stimulants such as acetylcholine, oxytocinand prostaglandin F2alpha.
Flunitrazepam induces geometrical changes at the lipid-water interface.


Caffeine acting on pregnant rat myometrium: analysis of its relaxant action and its failure to release Ca2+ from intracellular stores
It is suggested that the inability of caffeine to cause spasm of rat myometrium is due to the absence of a caffeine‐sensitive calcium‐release channel in the sarcoplasmic reticulum.
Prostaglandin synthesis inhibitors: effect on angiotensin II‐ and oxytocin‐induced contractions in rat uterine smooth muscle
  • M. M. Hall
  • Biology, Medicine
    British journal of pharmacology
  • 1983
It can be implied that some product of the arachidonate lipoxygenase pathway augments peptide‐induced contractions of the rat uterus.
Possible Mechanism of Benzodiazepine‐Induced Relaxation of Vascular Smooth Muscle
The data suggest that the relaxant effects of these agents are unrelated to the high-affinity benzodiazepine binding site and are probably mediated through inhibition of the voltage-operated calcium channel.
The spasmogenic action of oxytocin in the rat uterus – comparison with other agonists
It is concluded that the phasic component of the response of the uterus to oxytocin and bradykinin is associated with Ca2- influx via voltage‐dependent Ca2+ channels, and the tonic component is due to another mechanism(s) which does not appear to involve Ca2 + influx.
Antioquine: a new bisbenzylisoquinoleine alkaloid with calcium antagonist activity.
These experiments suggest that the relaxant effects produced by antioquine may be due to the blockade of calcium movements across the cell membrane, mainly through voltage-operated channels, whereas papaverine affects Ca2+-entry both through VOCs and through ROCs.
Role of stored Ca in contractions of rat uterus induced by acetylcholine: effects of preincubation with Mg-free solution.
The results suggest that Mg plays an interesting role in stimulus-contraction coupling mediated by acetylcholine in Ca-free medium and can be explained by a release of stored Ca caused by Mg or by a direct effect of the ion on contractile proteins.
Maintained contractions of rat uterine smooth muscle incubated in a Ca2+‐free solution
These results are consistent with the hypothesis that the maintained contractions in Ca2+‐free solutions induced by several stimulants could be related to Ca1+‐independent mechanisms (fluoride) or Ca2- release from an intracellular store.
Relaxation of rat vascular muscle by peripheral benzodiazepine modulators.
Effects of peripheral benzodiazepine receptor modulating drugs, Ro 5-4864 and PK 11195, on tension induced by K+ and the calcium agonist SDZ 202 791 (S isomer), were studied in rat caudal arteries. A