Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)

  title={Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs)},
  author={Nicolas Roydon Smoll},
  • N. Smoll
  • Published 1 March 2012
  • Medicine
  • Cancer
Medulloblastomas are 1 of the most common brain tumors in children but can affect individuals of all ages. For this report, the author investigated the impact of medulloblastomas/primitive neuroectodermal tumors (PNETs) on the US population with a focus on age differences. 

Suprasellar Primitive Neuroectodermal Tumor in an Adult.

A 31-year-old woman with bilateral vision loss and a bitemporal hemianopia is diagnosed with primitive neuroectodermal tumors, and neuroimaging revealed a suprasellar mass, and pathology was consistent with PNET.

Medulloblastomas: Survival Differences Between Children and Adults

Up to 4 years post-diagnosis, the prognosis remains the same, but between 4 and 10 years of follow-up, adults become significantly more likely to die than children.

Primitive Neuroectodermal Tumor, a Rare Cause of Musculoskeletal Manifestations in a Child

Among small blue round cell tumors, primitive neuroectodermal tumors (PNETs) are a group of Ewing sarcoma family of tumors that are highly aggressive, poorly differentiated and form a group of tumors

Primitive neuroectodermal tumors of the abdominal wall and vulva in children: Report of two cases and review of the literature

PNET is a rare, fast-growing, highly malignant tumor that requires histologic and molecular analyses for exact diagnosis, and multimodal treatment is required to achieve a good prognosis.

Adult Medulloblastoma: Updates on Current Management and Future Perspectives

The state of the art for adult medulloblastoma diagnosis and treatment is reviewed, presenting novel molecular advances and their therapeutic implications and discussing the central role of hub centers to guarantee the highest quality of care and a better overall outcome for this rare tumor.

Epidemiology of childhood brain tumors

This chapter reviews the descriptive and analytic epidemiology of childhood brain tumors, including a discussion of the roles of radiation exposure, established predisposing syndromes, and other suspected risk factors.

Incidence, Trends, and Survival of Children With Embryonal Tumors

A comprehensive overview of pediatric embryonal tumors from a well-established, complete nationwide cancer registry is presented, finding significant increasing trend for hepatoblastomas was detected for the first time in Europe.

Posterior Fossa Tumors in Adult Patients.

The incidence of medulloblastomas and primitive neurectodermal tumours in adults and children




Characteristics and outcomes of medulloblastoma in adults

The presentation, management, and outcome of patients with adult medulloblastoma treated at the McGill University teaching hospitals over the past 18 years are reviewed.

Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End Results.

It is found that medulloblastoma and PNET are histologically identical and have similar epidemiologic profiles, and future studies should provide analyses that combine these entities.

Epidemiology of adult medulloblastoma

The epidemiological data are consistent with an embryonal origin of medulloblastoma, which is higher than that generally assumed, and indicates that the occurrence of this embryonal tumor in adult age is relevant.

The value of surveillance testing in childhood brain tumors

Follow‐up procedures in children with brain tumors are designed to confirm tumor response to initial therapy, identify recurrence or progression at the time of potential secondary treatment, and

Adult medulloblastoma: multiagent chemotherapy.

In this study, the records of 17 adult patients with medulloblastoma treated with craniospinal radiation and 1 of 2 multiagent chemotherapy protocols were reviewed for progression-free survival,

Common strategy for adult and pediatric medulloblastoma: a multicenter series of 253 adults.

Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma.

The results demonstrated an encouraging survival rate for children with MB/PNET, especially those treated with aggressive surgical resection followed by both radiation therapy and chemotherapy, and suggest that chemotherapy has a role for some, and possibly all, children withMB/P NET.

Medulloblastoma in childhood: an epidemiological study.

Survival probability was statistically significantly better in the years 1968 to 1977 than in previous decades, in part due to fewer autopsy diagnoses and lowered operative mortality, but also due to a decreased mortality rate in children several years after diagnosis.

Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy.

The authors conclude that overall progression-free survival remains excellent for children with posterior fossa medulloblastomas treated with this drug regimen and Chemotherapy has a definite role in the management of children with medull Oblastoma.

Medulloblastoma in adults: a review of 47 patients treated between 1952 and 1981.

  • H. BloomE. Bessell
  • Medicine
    International journal of radiation oncology, biology, physics
  • 1990