Relative sensitivities of repair-deficient mammalian cells for clonogenic survival after alpha-particle irradiation.

@article{Hill2004RelativeSO,
  title={Relative sensitivities of repair-deficient mammalian cells for clonogenic survival after alpha-particle irradiation.},
  author={Mark A Hill and Michael T Herdman and David Lucas Stevens and Nigel John Jones and John Thacker and Dudley T. Goodhead},
  journal={Radiation research},
  year={2004},
  volume={162 6},
  pages={
          667-76
        }
}
The clonogenic survival of cells of the radiation-sensitive hamster cell lines irs1, irs2, irs3 and xrs5, representing different DNA repair pathways, was compared to that of their parent lines after alpha-particle irradiation. Measurements of nuclear area were made to calculate the probability of surviving a single alpha-particle traversal, the average number of lethal lesions per track and per unit dose, along with the "intrinsic radiosensitivity" of these cells, allowing for the potential of… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Relaying signals from DNA strand breaks

C. E. Canman, Checkpoint mediators
  • Curr. Biol. 13, R488–R490
  • 2003
VIEW 1 EXCERPT

Their roles in DNA repair and genetic stability

J. Thacker, M. Z. Zdzienicka, The mammalian XRCC genes
  • DNA Repair 2, 655– 672
  • 2003
VIEW 1 EXCERPT