Relative risk of prostate cancer for men with affected relatives: Systematic review and meta‐analysis

  title={Relative risk of prostate cancer for men with affected relatives: Systematic review and meta‐analysis},
  author={Deborah Watkins Bruner and Dirk F. Moore and Alicia Parlanti and Joanne F Dorgan and Paul F. Engstrom},
  journal={International Journal of Cancer},
An increased risk of prostate cancer associated with a family history of prostate cancer has been documented in multiple published reports. Risk has been shown to vary by degree of relationship and age of onset of disease in the affected relative. Several studies, using various designs, have estimated the relative risk (RR) for these associations. The purpose of our study was to identify and summarize published reports on the relationship between risk of prostate cancer and family history… 
What should a urologist know about hereditary predisposition to prostate cancer?
The increase in relative risk for men with a family history of the disease is essentially the same in all studied populations, but it is important to consider that the risk increases particularly for early-onset disease for relatives of men diagnosed at an early age.
Family history of cancer and the risk of prostate cancer and benign prostatic hyperplasia
We analysed the relation between family history of cancer in first‐degree relatives and risk of prostate cancer (PC) and benign prostatic hyperplasia (BPH) using data from a multicentric case‐control
Familial risk and familial survival in prostate cancer
  • K. Hemminki
  • Medicine, Psychology
    World Journal of Urology
  • 2011
Familial risks were somewhat higher for fatal prostate cancer than for incident prostate cancer, suggesting that fatal prostate cancers may be a genetic subgroup.
Family History of Prostate Cancer in a Black Population
In the PCBP study, a family history of PC in fathers or brothers was associated with a threefold increased risk of disease and a strong positive relationship was noted for the number of affected first degree relatives, and it remains unclear whether this finding is the result of an increased genetic susceptibility in African-Barbadian men.
Family history of breast cancer increases the risk of prostate cancer: results from the EPICAP study
A family history of BCa in first degree relatives before age 50 may increases the risk of PCa with higher Gleason score, and this finding could suggest a specific prostate surveillance and/or genetic counselling for men who present such familial history.
An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis
The combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65).
Measures of familial aggregation depend on definition of family history: meta-analysis for colorectal cancer.
First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis
It is demonstrated that men with a family history of female breast cancer in first-degree relatives had an increased risk of prostate cancer, including risk of lethal prostate cancer.


Family history and the risk of breast cancer: A systematic review and meta‐analysis
The aim of this study was to identify all the published studies which have quantified the risk of breast cancer associated with a family history of the disease, and to summarise the evidence, with particular emphasis on age‐specific risks according to subject and relative age.
Family history and prostate cancer risk.
Familiar factors are significantly associated with the risk of prostate cancer and the association was present both among men with local and advanced stage disease and among men whose prostate cancer was detected either by screening or because of symptoms.
Family History and Risk of Fatal Prostate Cancer
Results from Cox proportional hazard models showed that family history of prostate cancer was related to fatal prostate cancer, and a 60% increase in risk for men with at least one affected relative is lower than that reported in previous studies.
Family History of Breast Cancer as a Predictor for atal Prostate Cancer
Data from a prospective mortality study of adult men in the United States showed a modest increased risk of fatal prostate cancer associated with a family history of breast cancer, and the association was stronger among men younger than 65 years of age whose relatives were diagnosed with breast cancer before age 50 years.
Family history and prostate cancer risk in a population-based cohort of Iowa men.
  • J. Cerhan, A. Parker, K. Cantor
  • Medicine, Biology
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1999
Data from an incidence study confirm that a family history of prostate cancer is a strong prostate cancer risk factor after adjustment for dietary and other risk factors, and suggest that selection and recall bias have not had an important influence on most case-control study results.
Family history of prostate cancer: A multi‐center case‐control study in Canada
This study provides further evidence of familial aggregation of prostate cancer, and suggests the possibility that part or all of such clustering could be related to inherited genetic patterns; if so, the availability of screening procedures for the disease offers the possibility of useful early intervention in individuals with such inherited susceptibility.
A case-cohort study on prostate cancer risk in relation to family history of prostate cancer.
The associations the authors observed were stronger for cases diagnosed before age 70 compared with cases diagnosed after age 70 and for advanced compared with localized tumors.