Relative resistance of human CD4(+) memory T cells to suppression by CD4(+) CD25(+) regulatory T cells.

@article{Afzali2011RelativeRO,
  title={Relative resistance of human CD4(+) memory T cells to suppression by CD4(+) CD25(+) regulatory T cells.},
  author={Behdad Afzali and Philip J. Mitchell and Cristiano Scott{\'a} and Jane L Canavan and Francis C. Edozie and Henrieta Fazekasova and Graham M Lord and Susan D. John and Linda D. Barber and Maria P Hernandez-Fuentes and R. Lechler and Giovanna Lombardi},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2011},
  volume={11 8},
  pages={1734-42}
}
Successful expansion of functional CD4(+) CD25(+) regulatory T cells (T(reg)) ex vivo under good manufacturing practice conditions has made T(reg) -cell therapy in clinical transplant tolerance induction a feasible possibility. In animals, T(reg) cells home to both transplanted tissues and local lymph nodes and are optimally suppressive if active at both sites. Therefore, they have the opportunity to suppress both naïve and memory CD4(+) CD25(-) T cells (Tresp). Clinical transplantation… CONTINUE READING

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