Relative reinforcing strength of three N-methyl-D-aspartate antagonists with different onsets of action.

@article{Winger2002RelativeRS,
  title={Relative reinforcing strength of three N-methyl-D-aspartate antagonists with different onsets of action.},
  author={Gail D. Winger and Steven R. Hursh and Kenneth L. Casey and James H. Woods},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={301 2},
  pages={
          690-7
        }
}
  • G. Winger, S. Hursh, J. Woods
  • Published 1 May 2002
  • Psychology, Biology
  • The Journal of pharmacology and experimental therapeutics
The potential contribution of onset and duration of pharmacological action to the reinforcing strength of three intravenously delivered N-methyl-D-aspartate antagonists was evaluated in this study. The onsets and durations of action of ketamine, phencyclidine, and dizocilpine were evaluated by observation and tabulation of their behavioral effects in rhesus monkeys after i.v. administration. The reinforcing effects of each drug were tested in a paradigm in which the fixed ratio requirements for… 
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