Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow.

@article{Won2007RelativeRO,
  title={Relative reduction of endothelial nitric-oxide synthase expression and transcription in atherosclerosis-prone regions of the mouse aorta and in an in vitro model of disturbed flow.},
  author={Doyon Won and S Zhu and Mian Chen and A M Teichert and Jason E. Fish and C C Matouk and Michael Bonert and Matadial Ojha and Philip A. Marsden and Myron I Cybulsky},
  journal={The American journal of pathology},
  year={2007},
  volume={171 5},
  pages={1691-704}
}
Atherosclerosis develops in distinct regions of the arterial tree. Defining patterns and mechanisms of endothelial cell gene expression in different regions of normal arteries is key to understanding the initial molecular events in atherogenesis. In this study, we demonstrated that the expression of endothelial nitric-oxide synthase (eNOS), an atheroprotective gene, and its phosphorylation on Ser(1177), a marker of activity, were lower in regions of the normal mouse aorta that are predisposed… CONTINUE READING