Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells.

@article{Swales2003RelativeRE,
  title={Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells.},
  author={Kim Swales and N Plant and Andrew Ayrton and Suzanne Hood and Gordon D. Gibson},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2003},
  volume={33 7},
  pages={
          703-16
        }
}
1. Species differences in xenobiotic-mediated transcriptional activation of CYP3A genes are known to exist. These differences are proposed to be due, in part, to host cell differences. 2. Host cell effects were investigated by trans-species transient transfection of reporter genes containing either the rat CYP3A23 or human CYP3A4 proximal promoters into human HepG2 and rat FaO and H4IIEC3 hepatoma cells. HepG2 and FaO cells supported activation of both CYP3A constructs by xenobiotics in a… CONTINUE READING

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