Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia.

@article{Woo2004RelativeRO,
  title={Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia.},
  author={Patrick C. Y. Woo and Susanna K. P. Lau and Hoi-wah Tsoi and Kwok-hung Chan and Beatrice H. L. Wong and Xiao-yan Che and Victoria K P Tam and Sidney Chi-Fai Tam and Vincent Chi Chung Cheng and Ivan F. N. Hung and Samson Sai-yin Wong and Bo-jian Zheng and Yi Guan and Kwok-yung Yuen},
  journal={Lancet},
  year={2004},
  volume={363 9412},
  pages={841-5}
}
BACKGROUND Although the genome of severe acute respiratory syndrome coronavirus (SARS-CoV) has been sequenced and a possible animal reservoir identified, seroprevalence studies and mass screening for detection of subclinical and non-pneumonic infections are still lacking. METHODS We cloned and purified the nucleocapsid protein and spike polypeptide of SARS-CoV and examined their immunogenicity with serum from patients with SARS-CoV pneumonia. An ELISA based on recombinant nucleocapsid protein… CONTINUE READING