Relative rates of insertion and deletion mutations in dinucleotide repeats of various lengths in mismatch repair proficient mouse and mismatch repair deficient human cells.

@article{Yamada2002RelativeRO,
  title={Relative rates of insertion and deletion mutations in dinucleotide repeats of various lengths in mismatch repair proficient mouse and mismatch repair deficient human cells.},
  author={Nazumi Alice Yamada and Gwynedd A Smith and Anay Castro and Carmen N. Roques and Jayne C Boyer and Rosann A. Farber},
  journal={Mutation research},
  year={2002},
  volume={499 2},
  pages={213-25}
}
Microsatellites are DNA elements composed of short tandem repeats of 1-5bp. These sequences are particularly prone to frameshift mutation by insertion-deletion loop formation during replication. The mismatch repair system is responsible for correcting these replication errors, and microsatellite mutation rates are significantly elevated in the absence of mismatch repair. We have investigated the effect of varying the number of repeats in a (CA)n microsatellite on mutation rates in cultured… CONTINUE READING