Corpus ID: 29550672

Relative number and proliferation kinetics of hemopoietic stem cells in the mouse.

@article{Siegers1979RelativeNA,
  title={Relative number and proliferation kinetics of hemopoietic stem cells in the mouse.},
  author={M. Siegers and L. Feinendegen and S. Lahiri and E. Cronkite},
  journal={Blood cells},
  year={1979},
  volume={5 2},
  pages={
          211-36
        }
}
  • M. Siegers, L. Feinendegen, +1 author E. Cronkite
  • Published 1979
  • Biology, Medicine
  • Blood cells
  • A model calculation of the hemopoiesis of the mouse based on known hematologic data leads to the conclusion that approximately 3% of all nucleated bone marrow cells are stem cells (pluripotent plus committed stem cells). By a new 125IUdR labeling technique on radiation chimeras, a relative number of 2%-7% stem cells was determined. In previous studies with test systems for stem cells using colony formation in vivo or in vitro, a relative number of stem cells of at least one order of magnitude… CONTINUE READING

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