Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation.

@article{Zhao2014RelativeMB,
  title={Relative motions between left flipper and dorsal fin domains favour P2X4 receptor activation.},
  author={Wen-Shan Zhao and Jin Wang and Xiao-juan Ma and Yang Yang and Yan Liu and Li-dong Huang and Ying-Zhe Fan and Xiao-Yang Cheng and Hong-zhuan Chen and Rebecca Wang and Ye Jie Yu},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={
          4189
        }
}
Channel gating in response to extracellular ATP is a fundamental process for the physiological functions of P2X receptors. Here we identify coordinated allosteric changes in the left flipper (LF) and dorsal fin (DF) domains that couple ATP-binding to channel gating. Engineered disulphide crosslinking or zinc bridges between the LF and DF domains that constrain their relative motions significantly influence channel gating of P2X4 receptors, confirming the essential role of these allosteric… CONTINUE READING
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