Relative lung and total systemic bioavailability following inhalation from a metered dose inhaler compared with a metered dose inhaler attached to a large volume plastic spacer and a jet nebuliser

@article{Silkstone2001RelativeLA,
  title={Relative lung and total systemic bioavailability following inhalation from a metered dose inhaler compared with a metered dose inhaler attached to a large volume plastic spacer and a jet nebuliser},
  author={Victoria Louise Silkstone and Sarah A Corlett and Henry Chrystyn},
  journal={European Journal of Clinical Pharmacology},
  year={2001},
  volume={57},
  pages={781-786}
}
Objective: To compare the lung and systemic delivery of salbutamol following inhalation from a metered dose inhaler (MDI), a MDI attached to a spacer (MDI+SP) and a nebuliser (NEB) using a urinary pharmacokinetic method. Method: Twelve healthy subjects each provided urine samples at 0, 30 min and pooled up to 24 h after the start of 5×100 µg salbutamol inhaled from MDI and MDI+SP and after 2.5 mg was delivered by NEB. Following nebulisation, the amount of salbutamol trapped on an exhalation… CONTINUE READING
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