Relative location of inhibitory synapses and persistent inward currents determines the magnitude and mode of synaptic amplification in motoneurons.

@article{Bui2008RelativeLO,
  title={Relative location of inhibitory synapses and persistent inward currents determines the magnitude and mode of synaptic amplification in motoneurons.},
  author={Tuan Vu Bui and Giovanbattista Grande and Philippa Rose},
  journal={Journal of neurophysiology},
  year={2008},
  volume={99 2},
  pages={583-94}
}
In some motoneurons, L-type Ca2+ channels that partly mediate persistent inward currents (PICs) have been estimated to be arranged in 50- to 200-microm-long discrete regions in the dendrites, centered 100 to 400 microm from the soma. As a consequence of this nonuniform distribution, the interaction between synaptic inputs to motoneurons and these channels may vary according to the distribution of the synapses. For instance, >93% of synapses from Renshaw cells have been observed to be located 65… CONTINUE READING

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