Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model.

@article{Klonisch1996RelativeLO,
  title={Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model.},
  author={Th. Klonisch and Peter J. Delves and Peter Berger and George N Panayotou and Adrian Jonathan Lapthorn and Neil W. Isaacs and Georg Wick and Torben Ellegaard Lund and Ivan M. Roitt},
  journal={European journal of immunology},
  year={1996},
  volume={26 8},
  pages={1897-905}
}
We systematically screened a large panel of well-characterized monoclonal antibodies (mAb) directed towards various epitopes on human chorionic gonadotropin (hCG) for synergistic binding of 125I-hCG when they were adsorbed to a solid phase. The epitope locations involved in synergy were then related to the crystal structure of hCG and discussed in… CONTINUE READING