Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax

@article{Shinoura1999RelativeLO,
  title={Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax},
  author={Nobusada Shinoura and Yoko Yoshida and Akio Asai and Takaaki Kirino and Hirofumi Hamada},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={5703-5713}
}
The Bax protein plays a critical role in the apoptosis of cancers induced by radiotherapy or chemotherapy, which induce both apoptosis and necrosis. We transduced various glioblastoma cells with the Bax gene via an adenoviral vector and found that A-172 cells led to necrotic cell death, while U251 cells apoptotic cell death, even though a similar level of Bax protein was introduced. A-172 cells displayed a much higher constitutive expression of the Bcl-XL protein compared with that of U251… CONTINUE READING
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