Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride.

@article{Autissier2007RelativeIV,
  title={Relative in vitro efficacy of the phosphate binders lanthanum carbonate and sevelamer hydrochloride.},
  author={Valerie Autissier and Stephen J.P. Damment and Richard A. Henderson},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 10},
  pages={
          2818-27
        }
}
The high tablet burden and poor compliance associated with phosphate-binding drugs has led to a search for more potent agents. In vitro-binding studies were performed on the recently introduced binder, lanthanum carbonate (LC; Fosrenol), to compare its phosphate-binding affinity with sevelamer hydrochloride (SH; Renagel). Langmuir equilibrium binding affinities (K(1)) for LC and SH were established using different phosphorus (5-100 mM) and binder (134-670 mg per 50 mL) concentrations at pH 3-7… CONTINUE READING

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