Relative importance of intracellular glutathione peroxidase and catalase in vivo for prevention of peroxidation to the heart.

@article{Simmons1989RelativeIO,
  title={Relative importance of intracellular glutathione peroxidase and catalase in vivo for prevention of peroxidation to the heart.},
  author={Todd W Simmons and I. Siraj Jamall},
  journal={Cardiovascular research},
  year={1989},
  volume={23 9},
  pages={774-9}
}
The relative importance in vivo of catalase and the selenoenzyme glutathione peroxidase for protection against peroxidation was assessed in the rat heart. Each of these enzymes was modulated by feeding animals a low selenium diet either unsupplemented or supplemented with 0.5 parts per million of selenium, with or without the catalase inhibitor, 3-amino-1,2,4-triazole, in their drinking water. After 8 weeks, selenium deficient rats had 88% reductions in cytosolic and mitochondrial glutathione… CONTINUE READING

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