Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.

@article{Xia2013RelativeIO,
  title={Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.},
  author={Zebin Xia and X. Cao and E. Rico-Bautista and Jinghua Yu and Liqun Chen and Jiebo Chen and A. Bobkov and D. Wolf and X. Zhang and M. Dawson},
  journal={MedChemComm},
  year={2013},
  volume={4 2},
  pages={
          332-339
        }
}
A novel and the shortest route, thus far, for preparing cytosporone B (Csn-B) is reported. Csn-B and two analogs were used to probe the importance of hydroxyl groups at the 3- and 5-positions of the Csn-B benzene ring in inhibiting the viability of human H460 lung cancer and LNCaP prostate cancer cells, inducing H460 cell apoptosis, and interacting with the NR4A1 (TR3) ligand-binding domain (LBD). These studies indicate that Csn-B and 5-Me-Csn-B, having a phenolic hydroxyl at the 3-position of… Expand
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