Relative genotoxic potency of arsenic and its methylated metabolites.

@article{Moore1997RelativeGP,
  title={Relative genotoxic potency of arsenic and its methylated metabolites.},
  author={Martha M. Moore and Karen Harrington-Brock and Carolyn L. Doerr},
  journal={Mutation research},
  year={1997},
  volume={386 3},
  pages={
          279-90
        }
}
Arsenic is one of the few identified human carcinogens that has yet to be shown to cause cancer in rodents when the standard bioassay protocols are used. The reasons for this apparent interspecies difference are unclear but may be related to differences between humans and rodents in their detoxification capabilities. Detoxification of arsenic may occur through a methylation pathway. If, in fact, methylation does detoxify arsenic, one would predict that the methylated arsenicals might be less… CONTINUE READING

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