Relative equilibrium plot improves graphical analysis and allows bias correction of standardized uptake value ratio in quantitative 11C-PiB PET studies.

@article{Zhou2012RelativeEP,
  title={Relative equilibrium plot improves graphical analysis and allows bias correction of standardized uptake value ratio in quantitative 11C-PiB PET studies.},
  author={Yun Zhou and Jitka Sojkova and Susan M. Resnick and Dean F. Wong},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2012},
  volume={53 4},
  pages={622-8}
}
UNLABELLED Both the standardized uptake value ratio (SUVR) and the Logan plot result in biased distribution volume ratios (DVRs) in ligand-receptor dynamic PET studies. The objective of this study was to use a recently developed relative equilibrium-based graphical (RE) plot method to improve and simplify the 2 commonly used methods for quantification of (11)C-Pittsburgh compound B ((11)C-PiB) PET. METHODS The overestimation of DVR in SUVR was analyzed theoretically using the Logan and the RE… CONTINUE READING
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