Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay.

@article{Strikwold2012RelativeEP,
  title={Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay.},
  author={Marije Strikwold and Ruud A. Woutersen and Bert Spenkelink and Ans Punt and Ivonne M C M Rietjens},
  journal={Toxicology letters},
  year={2012},
  volume={213 2},
  pages={235-42}
}
The applicability of the embryonic stem cell test (EST) as an alternative for in vivo embryotoxicity testing was evaluated for a series of five p-substituted phenols. To this purpose, the potency ranking for this class of compounds derived from the inhibition of cardiomyocyte differentiation in the EST was compared to in vivo embryotoxic potency data obtained from literature and to the potency ranking defined in the in vitro whole embryo culture (WEC) assay. From the results obtained it appears… CONTINUE READING
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