Relative efficacy and critical interval of antimicrobial agents in experimental infections involving bacteroides fragilis.

@article{Bartlett1983RelativeEA,
  title={Relative efficacy and critical interval of antimicrobial agents in experimental infections involving bacteroides fragilis.},
  author={John G. Bartlett and Manouchehr Dezfulian and Keith A. Joiner},
  journal={Archives of surgery},
  year={1983},
  volume={118 2},
  pages={181-4}
}
Activity of seven antimicrobial agents was examined using a mouse model of a subcutaneous infection that involved Bacteroides fragilis. Untreated mice had encapsulated abscesses with approximately 10(10) bacteria. Pharmacokinetic studies showed that all drugs tested penetrated into abscesses to provide mean peak levels that were 17% to 53% of mean peak… CONTINUE READING