Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.

@article{Burkey1997RelativeEO,
  title={Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.},
  author={Thomas H Burkey and Raymond M. Quock and Paul F. Consroe and Frederick J. Ehlert and Yoshiaki Hosohata and W. R{\"o}ske and Henry I. Yamamura},
  journal={European journal of pharmacology},
  year={1997},
  volume={336 2-3},
  pages={295-8}
}
We measured (-)-5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohe xyl]-phenol (CP 55,940)-, (-)11-OH-delta8-tetrahydrocannabinol-dimethylheptyl (HU-210)-, anandamide- and delta9-tetrahydrocannabinol-stimulated G protein activation in mouse brain using the [35S]GTPgammaS functional assay. The Ki values for these drugs were determined by agonist competition binding with the cannabinoid CB1 receptor antagonist [3H]N-(piperidin-1-yl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4- methyl… CONTINUE READING

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