Relative effects of S-adenosylmethionine depletion on nucleic acid methylation and polyamine biosynthesis.

Abstract

Treatment of cultured L1210 cells with 1 mM-L-2-amino-4-methoxy-cis-but-3-enoic acid (L-cisAMB), a methionine-analogue inhibitor of S-adenosylmethionine (AdoMet) synthetase (EC 2.5.1.6), produced a rapid and near-total depletion of AdoMet by 4 h. After this, the pools recovered to 60% of control by 48 h, apparently because of an increase in AdoMet… (More)

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@article{Kramer1987RelativeEO, title={Relative effects of S-adenosylmethionine depletion on nucleic acid methylation and polyamine biosynthesis.}, author={Donald L. Kramer and Janice R. Sufrin and Carl W. Porter}, journal={The Biochemical journal}, year={1987}, volume={247 2}, pages={259-65} }