Relative dose intensity and therapy efficacy in different breast cancer molecular subtypes: a retrospective study of early stage breast cancer patients treated with neoadjuvant chemotherapy

@article{Yuan2015RelativeDI,
  title={Relative dose intensity and therapy efficacy in different breast cancer molecular subtypes: a retrospective study of early stage breast cancer patients treated with neoadjuvant chemotherapy},
  author={Jia-qi Yuan and Shou-man Wang and Li–li Tang and Jie Mao and Yu-hui Wu and Jian Hai and Sha-yang Luo and Hui-ying Ou and Lei Guo and Li-qiu Liao and Jun Huang and Yan Li and Zhi Xiao and Ke-jing Zhang and Na Luo and Fei-yu Chen},
  journal={Breast Cancer Research and Treatment},
  year={2015},
  volume={151},
  pages={405-413}
}
To investigate the relationship between chemotherapy dose intensity and therapy efficacy of different molecular subtypes. Clinical and pathological features of the patients with breast cancer were retreived from the hospital records. 315 patients were analyzed (251 showed clinical response, 38 acquired pCR). Patients with positive ER status, negative PR status, higher Ki67 level and higher RTDI had better therapy response. 13.5 and 84.5 % were identified the benchmark of Ki67 and RTDI… CONTINUE READING