Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine

@article{Giancarlo2001RelativeCO,
  title={Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine},
  author={Gina M. Giancarlo and Karthik Venkatakrishnan and Brian W. Granda and Lisa L. von Moltke and David J Greenblatt},
  journal={European Journal of Clinical Pharmacology},
  year={2001},
  volume={57},
  pages={31-36}
}
Objectives: To determine the relative contribution of cytochromes P 450 (CYP) 2C9 and 2C19 to the formation of 5-(-4-hydroxyphenyl)-5-phenylhydantion (HPPH) from phenytoin (PPH). Design: Hydroxylation of PPH to form HPPH was studied in vitro using human liver microsomes and microsomes from cDNA-transfected human lymphoblastoid cells. Results: Formation of HPPH from PPH in liver microsomes had a mean (±SEM) apparent Km [substrate concentration corresponding to 50% of maximal reaction velocity… CONTINUE READING

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