Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.

@article{Talmud2002RelativeCO,
  title={Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.},
  author={Philippa J. Talmud and Emma Hawe and Steve Martin and Michael Olivier and George J. Miller and Edward M. Rubin and Len A. Pennacchio and Steve E Humphries},
  journal={Human molecular genetics},
  year={2002},
  volume={11 24},
  pages={3039-46}
}
Since triglycerides (TG) are a major independent risk factor for coronary heart disease, understanding their genetic and environmental determinants is of major importance. Mouse models indicate an inverse relationship between levels of the newly identified apolipoprotein AV (APOAV) and TG concentrations. We have examined the relative influence of human APOA5 variants on plasma lipids, compared to the impact of variation in APOC3 and APOA4 which lie in the same cluster. Single nucleotide… CONTINUE READING
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