Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets.

@article{Hausser2009RelativeCO,
  title={Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets.},
  author={Jean Hausser and Markus Landthaler and Lukasz Jaskiewicz and Dimos Gaidatzis and Mihaela Zavolan},
  journal={Genome research},
  year={2009},
  volume={19 11},
  pages={2009-20}
}
How miRNAs recognize their target sites is a puzzle that many experimental and computational studies aimed to solve. Several features, such as perfect pairing of the miRNA seed, additional pairing in the 3' region of the miRNA, relative position in the 3' UTR, and the A/U content of the environment of the putative site, have been found to be relevant. Here we have used a large number of previously published data sets to assess the power that various sequence and structure features have in… CONTINUE READING

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