Relative contribution of peripheral versus central opioid receptors to antinociception

@article{Labuz2007RelativeCO,
  title={Relative contribution of peripheral versus central opioid receptors to antinociception},
  author={Dominika Labuz and Shaaban A Mousa and Michael Sch{\"a}fer and Christopher Stein and Halina Machelska},
  journal={Brain Research},
  year={2007},
  volume={1160},
  pages={30-38}
}
Opioid effects are mediated by central and peripheral opioid receptors. Here we examine the relative contribution of each receptor population to antinociception elicited by systemically administered centrally penetrating opioids, and by loperamide (a peripherally restricted opioid). Nociception (abdominal writhes) was induced by intraperitoneally (i.p.) injected 0.6% acetic acid in mice. We analyzed opioid receptor expression in peritoneum by immunohistochemistry, antinociception after i.p… CONTINUE READING
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