Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia.

@article{Wang2001RelativeCO,
  title={Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia.},
  author={Le Wang and Sanjay Jayantilal Mehta and Sean Weicker and JamesR. Scott and Matthew Joseph and Habib Moshref Razavi and David G. McCormack},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={283 3},
  pages={
          694-9
        }
}
Acute lung injury is an important feature of sepsis and increased iNOS expression and NO production contribute to the pathogenesis of this syndrome. We generated bone marrow-transplanted chimeric mice with iNOS expression limited to either inflammatory or pulmonary parenchymal cells, and assessed pulmonary iNOS activity and systemic levels of NO metabolites in an endotoxemic model of sepsis. We found that while both pulmonary parenchymal cells and inflammatory cells contribute to the increased… CONTINUE READING
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