Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference.

@article{Snyder2004RelativeCO,
  title={Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference.},
  author={Peter Michael Snyder and Jennifer C. Steines and Diane R. Olson},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 6},
  pages={
          5042-6
        }
}
Epithelial Na+ transport is regulated in large part by mechanisms that control expression of the epithelial Na+ channel (ENaC) at the cell surface. Nedd4 and Nedd4-2 are candidates to control ENaC surface expression, but it is not known which of these proteins contributes to ENaC regulation in epithelia. To address this question, we used RNA interference to selectively reduce expression of Nedd4 or Nedd4-2. We found that endogenous Nedd4-2, but not Nedd4, negatively regulates ENaC in two… CONTINUE READING
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